About the lab:
Our work employs a variety of techniques ranging from oligo chip synthesis and library-based screening to iPS cell differentiation and live-cell imaging. We utilize a variety of model systems ranging from yeast to human cell culture to assure that the technologies we generate are applicable to a broad swath of the scientific community.
Our research group strives to push the boundaries of genetic engineering by developing new methods with which to modify and regulate eukaryotic genomes. We apply these tools ourselves or through collaboration to gain fundamental biological insights with a particular focus towards understanding neurodegenerative diseases and cancer.
Our team places a strong emphasis on mentoring, and values the opportunity to be able to train the next generation of budding scientists.
- Our paper on high-throughput genome editing was published in Nature Biotechnology.
- Method of using SNPs to track the abundance of individuals cells within a mixed pool was published in Genome Medicine.
- Our work using CRISPR activators to screen for lncRNAs with roles in cancer drug resistance was published in Cell. Great collaboration with the Pandolfi lab at Harvard.